Evaluation of White Matter Abnormality in Mild Alzheimer Disease and Mild Cognitive Impairment Using Diffusion Tensor Imaging: A Comparison of Tract-Based Spatial Statistics with Voxel-Based Morphometry
نویسندگان
چکیده
Hyun Kyung Lim, Sang Joon Kim, Choong Gon Choi, Jae-Hong Lee, Seong Yoon Kim, Hengjun J. Kim, Namkug Kim, Geon-Ho Jahng Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center Department of Psychiatry and Health Promotion Center, University of Ulsan College of Medicine, Asan Medical Center Division of Magnetic Resonance, Korea Basic Science Institute, Ochang-Eup, Korea Department of Radiology, Kyung Hee East-West Neo Medial Center, Kyung Hee University College of Medicine, Seoul, Korea
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Multimodal imaging evidence for axonal and myelin deterioration in amnestic mild cognitive impairment.
White matter (WM) microstructural declines have been demonstrated in Alzheimer's disease and amnestic mild cognitive impairment (aMCI). However, the pattern of WM microstructural changes in aMCI after controlling for WM atrophy is unknown. Here, we address this issue through joint consideration of aMCI alterations in fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusi...
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